Ester of salicylic acid and pyruvic acid



Patented od. 30, 1928.

SAMUEL LEWIS SUMMERS, OF FORT WASHINGTON, PENNSYLVANIA.

No Drawi lgi ESTER OI .SALICYLIC ACID AND PYRUVIC ACID.

Application filed June 30, 1925. Serial No. 40,683.

The primary object of this invention is to provide'a therapeutic agent, or remedial,

which will be found especially efiicacious in increasing the elimination of by-products resulting from defective metabolism-such as uric acidand in the treatment of neuralgia of a gouty origin.

In carrying out my invention,

new therapeutic I prepare the by heating a mixture of 138 parts of salicylic acid ((3 11 0 and 176 parts of pyruvic acid (CH .CO.COOH) for two hours under a reflux condenser at a temperature of 160 C. The resultant mass is then cooled, and is freed from any uncombined pyruvic acid, by crystallizing it out with alcohol.

The new product is in the form of yellowish white needles which are easily soluble in alcohol, benzene, or glacial acetic acid and has the following chemi The new prod sult of crystalliz cal formula COOH.

not is best obtained as the reingi, it out with hot ethyl alcohol -or other solvent-from the cooled mix ture aforesaid in which it is held in solution; and is chemically the pyruvic acid ester of salicylic acid.

When administered" internally the new product will be found a valuable def remedial for ective metabolism and the. ills incident thereto, and more particularly those of a gouty origin.

ple of the ingre Although I have specified a concrete examdients used in producing my new and useful therapeutic, it is to be understood the proportions specified, as well as the time period. involved, may be varied without departing from the scope of my invention as succinctly defined-by the appended claims.

Having thus described my invention, I claim: y

1. As a new therapeutic agent the chemical reaction product of salicylic acid and pyruvic acid substantially .in the proportions of 1 part of the former to 1.23 parts of the latter.

2. As a new therapeutic agent the chemical reaction product of 138 parts of salicylic acid and 176 parts of pyruv-ic acid.

3. The process of producing atherapeuti-c agent which consists in thoroughly -mixing 138 parts of salicylic acid with 176 parts of pyruvic acid, and maintaining said mixture under reflux condensing action for two hours. at a temperature of 160 C.

4. The process of producinga therapeutic agent which consists in' thoroughlymixing 138 parts of salicylic acid with 176 parts of pyruvic acid, maintaining said mixture under reflux condensing action for two hours at a temperature of 160 0., and then cooling the resultant product. p

5. The process of producing a therapeutic agent which consists in thoroughly mixing 138 parts of salicylic acid with 176 parts of pyruvic acid, maintaining the mixture under reflux condensing action for two hours at a temperature of 160 C., cooling the-resultant product, and then freeing any unconibined pyruvic acid by alcoholic crystallization.

In testimony whereof, I have hereunto signed my name at Ambler, Penna, this 24th day of June, 1925.

SAMUEL LEWIS SUMMERS. 

